Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
PA1-4145 detects GABA Receptor Associated Protein in human samples.
PA1-4145 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~14 kDa protein representing GABA Receptor Associated Protein in brain lysate.
The PA1- 4145 immunogen is a synthetic peptide corresponding to residues R(15) S E G E K I R K K Y P D R V P V(31) of human GABARAP.
Gamma-aminobutyric acid (GABA) is the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing in the central nervous system. It has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. GABARAP (GABAA receptor-associated protein) links GABAA receptors to the cytoskeleton and may play a role in intracellular transport of GABAA receptors and its interaction with the cytoskeleton. GABARAP belongs to the MAP1 or ATG8 like family and recent studies show that MAPK15/ERK8 is acting through interaction with ATG8 family proteins to regulate autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ25768; GABA(A) receptor-associated protein; GABARAP a; Gamma-aminobutyric acid receptor-associated protein; hypothetical protein; MGC120154; MGC120155; MM46
Gene Aliases: ATG8A; FLC3B; GABARAP; GABARAP-a; HT004; MM46
UniProt ID: (Human) O95166
Entrez Gene ID: (Human) 11337
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