Product References
Enhanced viability and function of mesenchymal stromal cell spheroids is mediated via autophagy induction.
Autophagy
Regmi S,Raut PK,Pathak S,Shrestha P,Park PH,Jeong JH
PA1-654A was used in Western Blotting to find that macroautophagy/autophagy was highly induced and ROS production was suppressed in MSC3D as compared to 2D-cultured MSCs (MSC2D).
Fri Oct 01 00:00:00 EDT 2021
Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43.
Autophagy
Donde A,Sun M,Jeong YH,Wen X,Ling J,Lin S,Braunstein K,Nie S,Wang S,Chen L,Wong PC
PA1-654A was used in Western Blot, Immunohistochemistry, Immunocytochemistry to suggest that the autophagy pathway is a therapeutic target for ALS-FTD and other disorders exhibiting TARDBP pathology.
Wed Apr 01 00:00:00 EDT 2020
Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43.
Autophagy
Donde A,Sun M,Jeong YH,Wen X,Ling J,Lin S,Braunstein K,Nie S,Wang S,Chen L,Wong PC
PA1-654A was used in Western Blot, Immunohistochemistry, Immunocytochemistry to suggest that the autophagy pathway is a therapeutic target for ALS-FTD and other disorders exhibiting TARDBP pathology.
Wed Apr 01 00:00:00 EDT 2020
Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43.
Autophagy
Donde A,Sun M,Jeong YH,Wen X,Ling J,Lin S,Braunstein K,Nie S,Wang S,Chen L,Wong PC
PA1-654A was used in Western Blot, Immunohistochemistry, Immunocytochemistry to suggest that the autophagy pathway is a therapeutic target for ALS-FTD and other disorders exhibiting TARDBP pathology.
Wed Apr 01 00:00:00 EDT 2020
Intracellular localization of polymyxins in human alveolar epithelial cells.
The Journal of antimicrobial chemotherapy
Ahmed MU,Velkov T,Zhou QT,Fulcher AJ,Callaghan J,Zhou F,Chan K,Azad MAK,Li J
PA1-654A was used in Immunocytochemistry-immunoflourescence to provide new mechanistic information on polymyxin-induced lung toxicity, which is vital for optimizing inhaled polymyxins in the clinic.
Tue Jan 01 00:00:00 EST 2019
Human plasma C3 is essential for the development of memory B, but not T, lymphocytes.
The Journal of allergy and clinical immunology
Jiménez-Reinoso A,Marin AV,Subias M,López-Lera A,Román-Ortiz E,Payne K,Ma CS,Arbore G,Kolev M,Freeley SJ,Kemper C,Tangye SG,Fernández-Malavé E,Rodríguez de Córdoba S,López-Trascasa M,Regueiro JR
PA1-654A was used in Immunocytochemistry-Immunofluorescence to study whether reduced plasma C3 levels could affect lymphocyte differentiation.
Thu Mar 01 00:00:00 EST 2018
The Rab11-binding protein RELCH/KIAA1468 controls intracellular cholesterol distribution.
The Journal of cell biology
Sobajima T,Yoshimura SI,Maeda T,Miyata H,Miyoshi E,Harada A
PA1-654A was used in Western Blotting to suggest that RELCH promotes nonvesicular cholesterol transport from recycling endosomes to the trans-Golgi network through membrane tethering.
Mon May 07 00:00:00 EDT 2018
Metformin exacerbates and simvastatin attenuates myelin damage in high fat diet-fed C57BL/6 J mice.
Neuropathology : official journal of the Japanese Society of Neuropathology
Ciric D,Martinovic T,Petricevic S,Trajkovic V,Bumbasirevic V,Kravic-Stevovic T
PA1-654A was used in Immunocytochemistry, Western Blot, Immunohistochemistry to investigate the effects of metformin and simvastatin on the ultrastructural characteristics of sciatic nerve fibers in mice leading to diabetic neuropathy.
Mon Oct 01 00:00:00 EDT 2018
Metformin exacerbates and simvastatin attenuates myelin damage in high fat diet-fed C57BL/6 J mice.
Neuropathology : official journal of the Japanese Society of Neuropathology
Ciric D,Martinovic T,Petricevic S,Trajkovic V,Bumbasirevic V,Kravic-Stevovic T
PA1-654A was used in Immunocytochemistry, Western Blot, Immunohistochemistry to investigate the effects of metformin and simvastatin on the ultrastructural characteristics of sciatic nerve fibers in mice leading to diabetic neuropathy.
Mon Oct 01 00:00:00 EDT 2018
PIKfyve activity regulates reformation of terminal storage lysosomes from endolysosomes.
Traffic (Copenhagen, Denmark)
Bissig C,Hurbain I,Raposo G,van Niel G
Published figure using LAMP1 polyclonal antibody (Product # PA1-654A) in Immunofluorescence
Wed Nov 01 00:00:00 EDT 2017
The PKD domain distinguishes the trafficking and amyloidogenic properties of the pigment cell protein PMEL and its homologue GPNMB.
Pigment cell & melanoma research
Theos AC,Watt B,Harper DC,Janczura KJ,Theos SC,Herman KE,Marks MS
PA1-654A was used in immunocytochemistry to study the role of the PKD domain and its gycosylation in the differences in trafficking and amyloidogenesis observed between PMEL and GPNMB
Mon Jul 01 00:00:00 EDT 2013
NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion.
Diabetes
Li N,Li B,Brun T,Deffert-Delbouille C,Mahiout Z,Daali Y,Ma XJ,Krause KH,Maechler P
PA1-654A was used in immunocytochemistry to study the role of cAMP/PKA in the mechanism by which NOX2-generated ROS impair insulin secretion
Thu Nov 01 00:00:00 EDT 2012
Retromer disruption promotes amyloidogenic APP processing.
Neurobiology of disease
Sullivan CP,Jay AG,Stack EC,Pakaluk M,Wadlinger E,Fine RE,Wells JM,Morin PJ
PA1-654A was used in immunocytochemistry to investigate the effect of retromer malfunction on amyloidogenic APP processing
Mon Aug 01 00:00:00 EDT 2011
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD.
Autophagy
Tresse E,Salomons FA,Vesa J,Bott LC,Kimonis V,Yao TP,Dantuma NP,Taylor JP
PA1-654A was used in immunocytochemistry to investigate the role of VCP/p97 on the maturation of autophagosome
Mon Feb 01 00:00:00 EST 2010
Actin cytoskeleton-dependent Rab GTPase-regulated angiotensin type I receptor lysosomal degradation studied by fluorescence lifetime imaging microscopy.
Journal of biomedical optics
Li H,Yu P,Sun Y,Felder RA,Periasamy A,Jose PA
PA1-654A was used in immunocytochemistry to investigate the angiotensin type 1 receptor subcellular trafficking and degradation
Mon Mar 14 00:00:00 EDT 2011