Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
PA3-040A detects glutamate transporter 1 (GLT-1) from rat tissues.
PA3-040A has been successfully used in Western blot and immunoprecipitation procedures. By Western blot, this antibody detects a ~61 kDa band representing GLT-1 from rat brain extract. This antibody may also detect one or more non-specific bands below 50 kDa that have not been identified.
The PA3-040A immunogen is a synthetic peptide corresponding to residues N(556) G K S A D C S V E E E P W K R E K(573) or rat GLT-1. While GLT-1, GLAST and EAAC1 share approximately 50% sequence homology, the sequence used to generate this product is unique to GLT-1.
Excitatory amino acid transporter 2 (EAAT2) is a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis (ALS.) Alternatively spliced transcript variants of this gene have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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