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PA5-16895 targets CD106 in IHC (P) and ICC/IF applications and shows reactivity with Human samples.
The PA5-16895 immunogen is recombinant protein encoding aa 26-176 of human CD105.
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
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