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Reproductive homeobox on X chromosome 2, also known as Reproductive homeobox (Rhox)2, is a recently identified nuclear protein product of a 12 X-linked novel Rhox family of homeobox-containing gene family membersthat plays an important role during postnatal testis development. The members of this family are characterized by a conserved 60-amino-acid DNA-binding homeodomain. These transcription factors not only play an important role in various developmental processes such as body-plan specification, pattern formation, and cell fate determination, but also in understanding the development and physiology of the human reproductive system.
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