MAP1 LC3A is a structural protein and a component of both MAP1A and MAP1B microtubule-binding complexes which mediate the physical interactions between microtubules and components of the cytoskeleton. A member of the MAP1LC3 family, LC3A is known to have an ubiquitin fold at the C-terminal region and 2 helices at the N-terminal region. The posttranslational modification of LC3A precursor molecule leads to cleavage by APG4B/ATG4B, resulting in the cytosolic form, LC3-I which is further activated and modified to form the membrane-bound form, LC3-II. LC3A, a mammalian homolog of yeast Atg8, plays an essential role in autophagy, leading to bulk degradation of cytoplasmic components by the lysosomal system where it acts as an adaptor protein between microtubules and autophagosomes. Abundant expression of LC3A is seen in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.
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Protein Aliases: ATG8E; Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; LC3; LC3A; MAP1 light chain 3-like protein 1; MAP1A/1B light chain 3 A; MAP1A/MAP1B LC3 A; MAP1A/MAP1B light chain 3 A; MAP1ALC3; MAP1BLC3; Microtubule-associated protein 1 light chain 3 alpha; microtubule-associated protein 1-light chain 3A; microtubule-associated proteins 1A/1B light chain 3; Microtubule-associated proteins 1A/1B light chain 3A; RP11-346K17.1
Gene Aliases: 1010001H21Rik; 4922501H04Rik; ATG8E; BOS_13394; LC3; LC3A; MAP1ALC3; MAP1BLC3; MAP1LC3A; zgc:77094