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This antibody is predicted to react with bovine and rat based on sequence homology.
Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity). Plays a role in the maintenance of long-term retrieval- induced memory in response to contextual fear (By similarity). Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass (By similarity). Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post- myocardial infarction (By similarity). Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling (By similarity).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Calcium/calmodulin-dependent protein kinase II inhibitor 1; calcium/calmodulin-dependent protein kinase II inhibitor alpha; CaMKII inhibitor protein alpha; CaMKII inhibitory protein alpha; CaMKIIN-alpha; CaMKIINalpha; mCaMKIINalpha; RP11-401M16.1
Gene Aliases: 1810006K23Rik; AI848599; AI891706; CAMK2N1; PRO1489
UniProt ID: (Human) Q7Z7J9, (Mouse) Q6QWF9
Entrez Gene ID: (Human) 55450, (Mouse) 66259
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