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Sperm binding proteins and their C-terminal peptides of the Sperm Associated Antigen 11 (SPAG11) family are found to play an important role in epididymal innate immunity in addition to their role in sperm maturation. SPAG11 peptides resulting due to cleavage at the furin-like proprotein convertase motif are reported in the epididymal fluid, ejaculate and on sperm and their antimicrobial activity demonstrated. SPAG11A belongs to this family and is also named as EP2, HE2. It has 4 isoforms produced by alternative splicing.
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Protein Aliases: Antimicrobial-like protein Bin-1b; epididymal protein 2A; He2; Human epididymis-specific protein 2; Protein EP2; Sperm antigen HE2; Sperm-associated antigen 11A; Sperm-associated antigen 11B
Gene Aliases: BIN1B; EDDM2A; EP2; HE2; SPAG11A; SPAG11B
UniProt ID: (Human) Q6PDA7
Entrez Gene ID: (Human) 653423
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