Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: TRAM-like protein; Translocating chain-associated membrane protein 2
Gene Aliases: KIAA0057; TRAM2
UniProt ID: (Human) Q15035
Entrez Gene ID: (Human) 9697
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