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Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids (taurocholate). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (By similarity). Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3- sulfate, therefore playing a role in the enterohepatic circulation of sterols. Able to transport eicosanoids such as prostaglandin E2 (By similarity).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: organic solute transporter alpha; Organic solute transporter subunit alpha; organic solute transporter, alpha subunit; OST-alpha; Solute carrier family 51 subunit alpha; solute carrier family 51, alpha subunit
Gene Aliases: OSTA; OSTalpha; SLC51A
UniProt ID: (Human) Q86UW1
Entrez Gene ID: (Human) 200931
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