Recommended positive controls: A549, HeLa, HepG2, HCT116.
Predicted reactivity: Mouse (95%), Rat (96%), Xenopus laevis (91%), Chicken (91%), Chimpanzee (100%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GlnRS; Glutamine--tRNA ligase; glutamine-tRNA synthetase; Glutaminyl-tRNA synthetase
Gene Aliases: GLNRS; MSCCA; PRO2195; QARS
UniProt ID: (Human) P47897
Entrez Gene ID: (Human) 5859
Molecular Function: ligase