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Recommended positive controls: 293T, HeLa, HepG2, mouse brain.
Predicted reactivity: Mouse (90%), Rat (88%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C3HC type 1; hematopoietic stem/progenitor cell protein 216; hNIPA; mNIPA; nuclear interacting partner of ALK; nuclear interacting partner of anaplastic lymphoma kinase (ALK); Nuclear-interacting partner of ALK; Nuclear-interacting partner of anaplastic lymphoma kinase; OTTHUMP00000212330; Zinc finger C3HC-type protein 1; zinc finger, C3HC-type containing 1
Gene Aliases: 1110054L24Rik; AU018540; AU019789; HSPC216; NIPA; ZC3HC1
UniProt ID: (Human) Q86WB0, (Mouse) Q80YV2
Entrez Gene ID: (Human) 51530, (Mouse) 232679
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