PA5-30288 targets ALDH1A2 in WB applications and shows reactivity with Human and mouse samples.
The PA5-30288 immunogen is recombinant fragment corresponding to a region within amino acids 2 and 245 of Human ALDH1A2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Three transcript variants encoding distinct isoforms have been identified for this gene.
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Protein Aliases: alcohol dehydrogenase family 1, subfamily A2; alcohol dehydrogenase family 1, subfamily A7; aldehyde dehydrogenase 1 family, member A2; Aldehyde dehydrogenase family 1 member A2; RALDH 2; RALDH(II); RALDH2; RALDH2-T; Retinal dehydrogenase 2; retinaldehyde dehydrogenase 2; Retinaldehyde-specific dehydrogenase type 2
Gene Aliases: ALDH1A2; Aldh1a7; AV116159; RALDH(II); Raldh1; RALDH2; RALDH2-T