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PA5-32187 targets PLAG1 in WB applications and shows reactivity with Human samples.
The PA5-32187 immunogen is recombinant fragment corresponding to a region within amino acids 33 and 288 of Human PLAG1.
Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene.
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