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PA5-32206 targets Gli1 in IHC (P) and WB applications and shows reactivity with Human and mouse samples.
The PA5-32206 immunogen is synthetic peptide corresponding to a region within amino acids 755 and 810 of Human Gli1.
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.
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