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Percent identity with other species by BLAST analysis: Human, Gorilla (100%) Monkey (94%).
The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. GPR25 is an intronless, orphan GPCR with highest homology to GPR15, angiotensin II type 1A receptor, and somatostatin receptor 5. GPR25 has been linked to arterial stiffness. Human GPR25 is cleaved at amino acid residues 315-316 by HIV-1 protease.
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