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A suggested positive control is SK-N-SH cell lysate.
PA5-34482 can be used with blocking peptide PEP-1524.
SHROOM family members play diverse roles in the development of the nervous system and other tissues. SHROOM3 is an actin-binding protein is a regulator of the microtubule cytoskeleton during epithelial morphogenesis and is sufficient and necessary to induce a redistribution of the microtubule regulator gamma-tubulin. It is necessary for both apiscobasal cell elongation and apical constriction in the neural epithelium. SHROOM3 has also been shown to be essential for cell shape changes and morphogenesis in the developing vertebrate gut, with its transcription relying on the Pitx1 transcription factor.
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Protein Aliases: F-actin-binding; F-actin-binding protein; hShrmL; Protein Shroom3; Shroom-related protein
Gene Aliases: APXL3; KIAA1481; MSTP013; SHRM; SHRML; SHROOM3
UniProt ID: (Human) Q8TF72
Entrez Gene ID: (Human) 57619
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