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Myeloid tumor related gene (MTGR1) is found deleted in acute myeloid leukemia. Overexpression of MTGR1 can stimulate AML1-MTG8 to induce GCSF- dependent proliferation of L-G cells and to interfere with AML1- dependent transcription. AML1/MTG8 functions as a complex with MTGR1 and that the complex might be important in promoting leukemogenesis.
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