This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene is located in a major X/Y block of homology and its most closely related cadherin superfamily member is located in this homologous region on the X chromosome. The protein is thought to play a fundamental role in cell-cell recognition essential for the segmental development and function of the central nervous system. Transcripts arising from alternative splicing encode isoforms with N- and C-terminal variation.
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Protein Aliases: PCDH-Y; protocadherin 22; Protocadherin on the Y chromosome; Protocadherin prostate cancer; Protocadherin-11; Protocadherin-11 Y-linked; Protocadherin-22; Protocadherin-PC
Gene Aliases: PCDH-PC; PCDH11; PCDH11Y; PCDH22; PCDHX; PCDHY
UniProt ID: (Human) Q9BZA8
Entrez Gene ID: (Human) 83259
Molecular Function: cadherin