In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human ATG4GB is observed.\r
Reconstitute at 0.2 mg/mL in sterile PBS.
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.
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Protein Aliases: APG4 autophagy 4 homolog A; ATG4 autophagy related 4 homolog A; AUT-like 2 cysteine endopeptidase; AUT-like 2, cysteine endopeptidase; autophagin 2; Autophagin-2; autophagy related 4A, cysteine peptidase; Autophagy-related cysteine endopeptidase 2; Autophagy-related protein 4 homolog A; Cysteine protease ATG4A; hAPG4A; MGC107179
Gene Aliases: APG4A; ATG4A; AUTL2
UniProt ID: (Human) Q8WYN0
Entrez Gene ID: (Human) 115201
Molecular Function: hydrolase