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Immunogen sequence: TPTDPGLDSA LEPSGDPHGK CLFDSYRLHD ESNQRTLTLS SSKDANILSE QMSLKEVLDA SVKEVGSSSS DVSGKESVPV EEPLRSRASL IEVDLSDLK
Highest antigen sequence identity to the following orthologs: Mouse - 66%, Rat - 65%.
Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24486153, PubMed:24706919, PubMed:24117850). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Calmodulin-regulated spectrin-associated protein 1; DKFZp434F195; FLJ31228
Gene Aliases: CAMSAP1
UniProt ID: (Human) A1L4L2
Entrez Gene ID: (Human) 157922
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