Immunogen sequence: ISDEDFLLLE LLHWFKEEFF HWVNNVLCSK CGGQTRSRDR SLLPSDDELK WGAKEVEDHY CDACQFSNRF PRYNNPEKLL ETRCGR
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 87%.
This gene encodes an enzyme that catalyzes hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl) asparagine residue to N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. The encoded enzyme may play a role in the proteasome-mediated degradation of misfolded glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: hPNGase; N-glycanase 1; NGLY1; Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Peptide:N-glycanase; PNG1; PNGase
Gene Aliases: CDDG; CDG1V; NGLY1; PNG1; PNGase
UniProt ID: (Human) Q96IV0
Entrez Gene ID: (Human) 55768
Molecular Function: hydrolase