Immunogen sequence: TFGLVDSDGPC YAVMVYNIVQ SWGVLIGDSV AIPEPNLRLH RIQHKGKDYS FSSVRVETPL LLVVNGKPQG SSSQAVATVA SRPQC
Highest antigen sequence identity to the following orthologs - mouse 93%, rat 94%.
Tetratricopeptide repeat protein 5 (TTC5) is a member of a diverse group of functionally distinct proteins that are characterized by containing one or more tetratricopeptide repeats. Each motif consists of two anti-parallel a-helices such that tandem arrays of TPR motifs generate a right-handed helical structure with an amphipathic channel that may serve to accommodate the complementary region of a target protein. While the exact function of TTC5 remains unclear, it is thought that the TPR motifs serve to mediate protein-protein interactions such as those seen with protein chaperones HSP70 and HSP90 and some proteins involved in cell stress response signaling pathways such as protein phosphatase 5, suggesting that TTC5 may also function via protein-protein interactions mediated by its TPR motifs.
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Protein Aliases: Strap; Stress-responsive activator of p300; Tetratricopeptide repeat protein 5; TPR repeat protein 5
Gene Aliases: Strap; TTC5
UniProt ID: (Human) Q8N0Z6
Entrez Gene ID: (Human) 91875