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This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 86%; Zebrafish: 93%
Immunogen is a synthetic peptide located within the following region: REYTAAVEAK QVAQQEAQRA QFLVEKAKQE QRQKIVQAEG EAEAAKMLGE
PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. This protein functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity. It is probably involved in regulating mitochondrial respiration activity and in aging.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: B-cell receptor-associated protein 37; B-cell receptor-associated protein BAP37; MGC117268; phb2; Prohibitin-2; Repressor of estrogen receptor activity
Gene Aliases: AU044498; BAP; Bap37; Bcap37; Phb2; REA
UniProt ID: (Mouse) O35129
Entrez Gene ID: (Mouse) 12034
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