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FIGURE: 1 / 2
Positive Samples: A375, HT-29, U-251MG, LO2, Mouse heart, Rat liver; Cellular Location: Cell membrane, Multi-pass membrane protein
Immunogen sequence: SDKLYQRKEP VISSVHTKVK GIAEVKEEIV ENGVKKLVHS VFDTADYTFP LQGNSFFVMT NFLKTEGQEQ RLCPEYPTRR TLCSSDRGCK KGWMDPQSKG IQTGRCVVYE GNQKTCEVSA WCPIEAVEEA PRPALLNSAE NFTVLIKNNI DFPGHNYTTR NILPGLNITC TFHKTQNPQC PIFRLGDIFR ETGDNFSDVA IQGGIMGIEI YWDCNLDRWF HHCRPKYSFR RLDDKTTNVS LYPGYNFRYA KYYKENNVEK RTLIKVFGIR FDILVFGTGG KFDIIQLV
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay criteria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ATP receptor; MGC20089; P2X purinoceptor 7; p2X receptor 7; P2X7; P2X7 purinoceptor; P2X7 receptor; P2Z; P2Z receptor; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 7; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7; purinergic receptor P2X7 variant A
Gene Aliases: AI467586; P2RX7; P2X(7); P2X7; P2X7R
UniProt ID: (Human) Q99572, (Rat) Q64663, (Mouse) Q9Z1M0
Entrez Gene ID: (Human) 5027, (Rat) 29665, (Mouse) 18439
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