Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: MGSAGRLHYL AMTAENPTPG DLAPAPLITC KLCLCEQSLD KMTTLQECQC IFCTACLKQY MQLAIREGCG SPITCPDMVC LNHGTLQEAE IACLVPVDQF QLYQRLKFER EVHLDPYRTW CPVADCQTVC PVASSDPGQP VLVECPSCHL KFCSCCKDAW HAEVSCRDSQ PIVLPTEHRA LFGTDAEAPI KQCPVCRVYI; Positive Samples: Mouse kidney, Rat liver, ; Cellular Location: Cytoplasm, Mitochondrion membrane, Single-pass membrane protein
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
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Protein Aliases: E3 ubiquitin-protein ligase RNF144B; IBR domain containing 2; IBR domain-containing protein 2; RING finger protein 144B
Gene Aliases: BC025007; E130105P19Rik; Ibrdc2; Pir2; Rnf144b
UniProt ID: (Mouse) Q8BKD6
Entrez Gene ID: (Mouse) 218215, (Rat) 364681
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