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ASAP2 is a multidomain protein belonging to the beta family with two ANK repeats, an Arf-GAP domain, a PH domain and a SH3 domain. This protein localizes in the Golgi apparatus and also at the plasma membrane where it colocalizes with protein tyrosine kinase 2-beta (PYK2) and forms a stable complex with PYK2 in vivo. ASAP2 is tyrosine phosphorylated by activated PYK2. It functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. ASAP2 activates the small GTPases ARF1, ARF5 and ARF6 and regulates the formation of post-Golgi vesicles and modulates constitutive secretion. It modulates phagocytosis mediated by Fc gamma receptor and ARF6. Usually detected in heart, brain, placenta, kidney, monocytes and pancreas, it is up-regulated during monocyte maturation. Multiple transcript variants encoding different isoforms have been found.
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Protein Aliases: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; centaurin, beta 3; development and differentiation enhancing factor 2; Development and differentiation-enhancing factor 2; PAG3; PAP; PAPbeta; Paxillin-associated protein with ARF GAP activity 3; PYK2 C terminus-associated protein; Pyk2 C-terminus-associated protein
Gene Aliases: 6530401G17Rik; AMAP2; ASAP2; CENTB3; DDEF2; Gm1523; Gm592; KIAA0400; PAG3; PAP; Pap-alpha; SHAG1
UniProt ID: (Human) O43150, (Mouse) Q66JN2
Entrez Gene ID: (Human) 8853, (Rat) 362719, (Mouse) 211914
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