Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
FIGURE: 1 / 1
Recommended positive controls: mouse brain.
Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hUpf2; nonsense mRNA reducing factor 2; Regulator of nonsense transcripts 2; smg-3 homolog, nonsense mediated mRNA decay factor; Up-frameshift suppressor 2 homolog; Upf2; yeast Upf2p homolog
Gene Aliases: HUPF2; KIAA1408; RENT2; smg-3; UPF2
UniProt ID: (Human) Q9HAU5, (Mouse) A2AT37
Entrez Gene ID: (Human) 26019, (Mouse) 326622
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