Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Recommended positive controls: A549, HeLa, HepG2, HCT116.
Predicted reactivity: Mouse (81%), Rat (81%), Rhesus Monkey (84%), Bovine (80%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DCTN3; dynactin 3 (p22); Dynactin complex subunit 22 kDa subunit; dynactin light chain; Dynactin subunit 3; MGC111190; p22
Gene Aliases: DCTN-22; DCTN22; DCTN3
UniProt ID: (Human) O75935
Entrez Gene ID: (Human) 11258
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