Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Recommended positive controls: 293T, A431, Raji.
Predicted reactivity: Mouse (83%), Rat (84%), Bovine (83%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Chromosome 17 is a hotspot for chromosomal aberrations in breast and ovarian cancer. Candidate oncogenes and tumor suppressors located on this chromosome include OVCA1 and OVCA2, p53, BRCA1, HER2/neu and others. OVCA1 and 2 map to a highly conserved region on human chromosome 17p13.3 that is deleted in 80% of ovarian cancers and shows frequent loss of heterozygosity in breast cancers. OVCA1 is induced by BRCA1 and is closely linked to p53, a well-known tumor suppressor gene. The close linkage of OVCA1 and p53 suggests that coordinated loss of the two genes may lead to ovarian, breast and other tumor types.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: candidate tumor suppressor in ovarian cancer 2; Esterase OVCA2; ovarian cancer gene-2 protein; Ovarian cancer-associated gene 2 protein
Gene Aliases: OVCA2
UniProt ID: (Human) Q8WZ82
Entrez Gene ID: (Human) 124641
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