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Peptide sequence: GDLEEAFKLF NLAKDIFPNE KVLSRIQKIQ EALEELAEQG DDEFTDVCNS
Sequence homology: Cow: 93%; Dog: 93%; Horse: 86%; Human: 100%; Pig: 86%; Rabbit: 93%; Rat: 79%
ERCC6L is a DNA helicase that acts as an essential component of the spindle assembly checkpoint. ERCC6L contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. ERCC6L acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ATP-dependent helicase ERCC6-like; DNA excision repair protein ERCC-6-like; excision repair cross-complementation group 6 like; excision repair cross-complementation group 6-like; excision repair cross-complementing rodent repair deficiency complementation group 6 - like; excision repair cross-complementing rodent repair deficiency, complementation group 6-like; excision repair protein ERCC6-like; FLJ20105; MGC131695; PLK1-interacting checkpoint helicase; SNF2/RAD54 family protein; Tumor antigen BJ-HCC-15
Gene Aliases: ERCC6L; PICH; RAD26L
UniProt ID: (Human) Q2NKX8
Entrez Gene ID: (Human) 54821
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