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Immunogen sequence: NLVGLKLPDL SEAAEQEKGL PSELSPAIEE EESKSGLDVM PNISDVLLRK LRVHRSLPGS APPLTEKEVE NVFVQLSLAF RNDSYTLESR INQAERERNL
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 90%.
This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during lymphoid differentiation. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, few of which initiate translation at a non-AUG (CUG) start site.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Inositol 1,4,5-triphosphate receptor associated 1; inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate; Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate; IP3R-associated cGMP kinase substrate; JAW1-related protein MRVI1; Protein MRVI1
Gene Aliases: IRAG; IRAG1; JAW1L; MRVI1
UniProt ID: (Human) Q9Y6F6
Entrez Gene ID: (Human) 10335
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