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Immunogen sequence: EKAKRSKRPT VPHDEDSSDD IAVGLTCQHV SHAISVNHVK RAIAENLWSV CSECLEERRF YDGQLVLTSD IWLCLKCGFQ
Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 81%.
The protein encoded by this gene is a deubiquitylase that binds ERCC1, the catalytic subunit of the XPF-ERCC1 DNA repair endonuclease. This endonuclease is a critical regulator of DNA repair processes, and the deubiquitylase activity of the encoded protein is important for maintaining the DNA repair ability of XPF-ERCC1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Deubiquitinating enzyme 45; Ubiquitin carboxyl-terminal hydrolase 45; ubiquitin specific protease 45; Ubiquitin thioesterase 45; ubiquitin thiolesterase 45; Ubiquitin-specific-processing protease 45
Gene Aliases: USP45
UniProt ID: (Human) Q70EL2
Entrez Gene ID: (Human) 85015
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