Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: RPADRQEENK AGLLDLPDAS VNGWSSDEEK AGGLDDEEEA ELVPSEVLMH QAIHTI
Highest antigen sequence identity to the following orthologs: Mouse - 62%, Rat - 62%.
The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles. Genetic defects in the gene encoding this protein a responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues. TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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