Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: PKLADRKLCA DQECSHPISM AVALQDYMAP DCRFLTIHRG QVVYVFSKLK GRGRLFWGGS VQGDYYGDLA ARLGYFPSSI VREDQTLKPG KVDVKTDKWD FYC
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 93%.
Tumorigenesis is a process that is mediated by a network of membrane, cytosolic and nuclear associated factors, which regulate proliferation and cell-matrix interaction through signaling cascades. The phenotype of malignant melanomas in vivo depends on the global expression of stimulatory or inhibitory factors generated in both the tumors cells and their environment. One example, Melanoma inhibitory activity (cartilage-derived retinoic acid-sensitive protein (CD-RAP), MIA) is a Src homology 3 (SH3)-like domain containing protein that is secreted from chondrocytes and malignant melanoma cells. MIA is translated as a 131-amino acid pro-form and processed into a mature 107-amino acid protein after cleavage of a secretion signal. MIA is expressed during chondrogenesis and in mature chondrocytes, suggesting that MIA is necessary for normal cartilage cell phenotype. MIA mRNA is present in carcinomas of the colon, ovary, kidney, and head/neck, and may represent a marker to monitor melanomic activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Melanoma inhibitory activity protein; Melanoma-derived growth regulatory protein
Gene Aliases: CD-RAP; MIA
UniProt ID: (Human) Q16674
Entrez Gene ID: (Human) 8190
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