Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Phospho-ANKRD28 (Ser1040) Polyclonal Antibody detects endogenous levels of ANKRD28 only when phosphorylated at Ser1040.
Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. ANKRD28 selectively regulated phosphorylation of hnRNP-K at ser284, an effect that was enhanced in vivo by an S1013A/S1017A double mutant, suggesting that ANKRD28 targets PP1 in a regulated manner to dephosphorylate hnRNP-K selectively at ser284.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Ankyrin repeat domain-containing protein 28; phosphatase interactor targeting K protein; Phosphatase interactor targeting protein hnRNP K; PITK; PP6-ARS-A; protein phosphatase 1, regulatory subunit 65; protein phosphatase 6 ankyrin repeat subunit A; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A; serine/threonine-protein phosphatase 6 regulatory subunit ARS-A
Gene Aliases: AI465466; AI604979; ANKRD28; E430019N21Rik; KIAA0379; mKIAA0379; PITK; PPP1R65
UniProt ID: (Human) O15084, (Mouse) Q505D1
Entrez Gene ID: (Human) 23243, (Mouse) 105522
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