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Immunogen sequence: GFPRIQQLFTS PESSVTAAPR ARKYKCGLPQ PCPEEHLAFR VVSGAANVIG
Highest antigen sequence identity to the following orthologs - mouse 88%, rat 90%.
A novel cytokine-like gene family using structure-based methods to search for novel four-helix-bundle cytokines in genomics databases. There are four genes in this family, FAM3A, FAM3B, FAM3C, and FAM3D, each encoding a protein (224-235 amino acids) with a hydrophobic leader sequence. Northern analysis indicates that FAM3B is highly expressed in pancreas, FAM3D in placenta, and FAM3A and FAM3C in almost all tissues. Immunohistochemistry showed that FAM3A is expressed prominently in the vascular endothelium, particularly capillaries. Fam3a staining in capillary endothelium and endocardium of heart, as well as vascular endothelial staining in many other tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cytokine-like protein 2-19; family with sequence similarity 3, member A; Protein FAM3A
Gene Aliases: 2-19; 2.19; DLD; DXS560S; FAM3A; XAP-7
UniProt ID: (Human) P98173
Entrez Gene ID: (Human) 60343
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