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Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. [UniProt]
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Protein Aliases: C184L ORF2 protein; C184M protein; Leucine repeat adapter protein 25; mammary tumor virus receptor 2; MMTV receptor; protein FAM89B
Gene Aliases: 1110021A21Rik; C184m; Fam89b; Lrap25; MMTV; Mtvr2
UniProt ID: (Mouse) Q9QUI1
Entrez Gene ID: (Mouse) 17826
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