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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Non-collagenous proteins of the small leucine-rich repeat (SLR) protein family are considered important components of the extracellular matrix. The extracellular matrix plays an integral role in the pivotal processes of development, tissue repair and metastasis by regulating cell proliferation, differentiation, adhesion and migration. Podocan, also known as PCAN, SLRR5A or PODN, is a 613 amino acid secreted protein belonging to the small leucine-rich proteoglycan (SLRP) family and the class V subfamily. Expressed in kidney, heart, liver, pancreas and vascular smooth muscle cells, Podocan exists as three alternatively spliced isoforms containing twenty LRR (leucine-rich repeats), a unique N-terminal cysteine-rich cluster pattern and a highly acidic C-terminal domain. Podocan is considered a glycoprotein containing N-linked oligosaccharides that may be involved in growth regulation in cardiovascular tissues. Encoded by a gene located on human chromosome 1, Podocan interacts type I collagen (COL1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Podocan; podocan proteoglycan; PRO332; UNQ293
Gene Aliases: 9430070G18; PCAN; PODN; SLRR5A; UNQ293/PRO332
UniProt ID: (Human) Q7Z5L7, (Mouse) Q7TQ62
Entrez Gene ID: (Human) 127435, (Mouse) 242608
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