Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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A 1:1,000 dilution of PA5-77812 was sufficient for detection of TCF7L2 in 15 µg of rat kidney cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.|Detects 68 kDa, band at approximately 55 kDa is another isoform, band at approximately 75 kDa is due to post translational modification.
TCF7L2, or TCF4, is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. TCF7L2 has been implicated in glucose homeostasis through the regulation of pro-glucagon gene expression, which encodes glucagon-like peptide 1 (GLP-1). Genetic variants of TCF7L2 have been linked to type 2 diabetes, and it has specifically been shown to have an important role in the regulation of both beta-cell survival and function. Several splicing isoforms for TCF7L2 have been shown to be differentially expressed in tissues during cancer progression, and gene targeting studies indicate that TCF7L2 is required to maintain the crypt stem cells of the small intestine.
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