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Positive Samples: SW480, BT-474; Cellular Location: Chromosome, Nucleus
Immunogen sequence: MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSI YVYKVLKQVH PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: H2b 613; H2B histone family, member Q; H2B-clustered histone 21; H2B/q; histone 2, H2be; Histone H2B type 2-E; Histone H2B-GL105; Histone H2B.q; Histone H2Bq
Gene Aliases: AV127319; GL105; H2B; H2b-613; H2B.1; H2BC21; H2BFQ; H2BGL105; H2BQ; HIST2H2BE; T25626
UniProt ID: (Human) Q16778, (Mouse) Q64524
Entrez Gene ID: (Human) 8349, (Mouse) 319190
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