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Immunogen sequence: KIITIEETHE ELKKQYIFQL SSLNPQERID YCHLIEKLGG LVIEKQCFDP TCTHIVVGHP LRNEKYLASV AAGKWVLHRS YLEACRTAGH FVQEEDYEWG SSSILDVLTG INVQQRRLAL AAMRWRKKIQ QRQESGIVEG AFSGWKVILH VDQSREAGFK RLLQSGGAKV LPGHSVPLFK EATHLFSDLN KLKPDDSGVN IAEAAAQNVY CLRTEYIADY LMQESPPHVE NYCLPEAISF IQNNKELGTG LSQKRKAPTE KNKIKRPRVH; Positive Samples: 293T; Cellular Location: Chromosome, Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center, spindle pole
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DNA topoisomerase 2-binding protein 1; DNA topoisomerase II-beta-binding protein 1; DNA topoisomerase II-binding protein 1; TOPBP 1; TopBP1; topoisomerase (DNA) II beta binding protein; topoisomerase (DNA) II binding protein 1
Gene Aliases: 1110031N14Rik; 2810429C13Rik; AI256758; D430026L04Rik; KIAA0259; mKIAA0259; RGD1562949; TOP2BP1; TOPBP1
UniProt ID: (Human) Q92547, (Mouse) Q6ZQF0
Entrez Gene ID: (Human) 11073, (Mouse) 235559, (Rat) 315969
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