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Immunogen sequence: LISDDEAEGS TTVRKEIIRN KIRAIGKMAR VFSILRQESE SVLTLKGLTP TGTLPLGVLS GGKQTIETAT VEAVEAREAI RGFSLQHKIR SFEEARGLDR INERMPPRKD SIHAGGPMKS VTSAHSHAAH RSDQGKKAHS; Positive Samples: Mouse testis, Rat brain
Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha, calcineurin A-beta, and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).
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Protein Aliases: Calcineurin A gamma; Calcineurin, testis-specific catalytic subunit; Calmodulin-dependent calcineurin A subunit gamma isoform; CAM-PRP catalytic subunit; protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma); protein phosphatase 3 catalytic subunit gamma; protein phosphatase 3, catalytic subunit, gamma isoform; Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Gene Aliases: Calnc; PP2BA gamma; Ppp3cc
UniProt ID: (Mouse) P48455
Entrez Gene ID: (Mouse) 19057, (Rat) 171378
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