Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: LKEDGFQPQS YLVQGVKALH TALKLWMKKE LVSEHAFEIP DNVRPGHLIK ELSKVIRAIE EENGKPVKSQ GIPSVCPVSR PSNEASPPYH SRRKMRKLRD HNVRTPSNLD ILELHTREVL KRLEMCPWEE DLLSSKLNGK FNKHLQPSST VPEWRAKDND LRLLLTNGRI IKDERQLFAD RSLYTADSEN EEDKKPTQNA NMKTEQSSGR EEAESQGSPK PLNRIFTSVR SELRSRPSEY SDGSDSEDSG PDCTALKINF ATEDSESSGD EKKHEITSHF KEESDIVRNL LQKSQKPSRQ EIPVKRECPT STSTEEEAI; Positive Samples: HeLa, 293T, BT-474, Mouse brain, Mouse thymus, Mouse spleen, Rat brain, Rat thymus; Cellular Location: Nucleus
JHDM1D histone demethylase that specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. This specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. This demethylates H3K9me2 in absence of H3K4me3.
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