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Product Details
67201-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1E3B1
Immunogen
PITX2 Fusion Protein Ag27924
Conjugate
Form
Liquid
Concentration
800 µg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
Pilx2 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. It plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this protein are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: all1-responsive gene 1; ALL1-responsive protein ARP1; Bicoid-related homeobox protein 1; BRX1 homeoprotein; Homeobox protein PITX2; homeodomain transcription factor 2; Orthodenticle-like homeobox 2; paired-like homeodomain 2; Paired-like homeodomain transcription factor 2; paired-like homeodomain transcription factor Munc 30; Pituitary homeobox 2; RIEG bicoid-related homeobox transcription factor; rieg bicoid-related homeobox transcription factor 1; rPtx2; S a 1 glycoprotein; S a1glycoprotein; S alpha 1 glycoprotein; S α 1 glycoprotein; S α1glycoprotein; Solurshin
Gene Aliases: 9430085M16Rik; ARP1; Brx1; Brx1b; IDG2; IGDS; IGDS2; IHG2; IRID2; Munc30; Otlx2; Pitx-2; PITX2; Pitx2c; PTX2; RGS; RIEG; RIEG1; RS
UniProt ID: (Human) Q99697, (Rat) Q9R0W1, (Mouse) P97474
Entrez Gene ID: (Human) 5308, (Rat) 54284, (Mouse) 18741
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II activating transcription factor binding
RNA polymerase II transcription coactivator activity
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
chromatin DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
transcriptional repressor activity, RNA polymerase II transcription factor binding
DNA binding
chromatin binding
identical protein binding
protein homodimerization activity
sequence-specific DNA binding
phosphoprotein binding
homeodomain transcription factor
patterning of blood vessels
vasculogenesis
in utero embryonic development
neuron migration
extraocular skeletal muscle development
atrioventricular valve development
cardiac neural crest cell migration involved in outflow tract morphogenesis
pulmonary myocardium development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
determination of left/right symmetry
myoblast fusion
male gonad development
female gonad development
response to hormone
Wnt signaling pathway
subthalamic nucleus development
hypothalamus cell migration
regulation of cell migration
embryonic camera-type eye development
response to vitamin A
embryonic hindlimb morphogenesis
hair cell differentiation
vascular smooth muscle cell differentiation
deltoid tuberosity development
odontogenesis of dentin-containing tooth
odontogenesis
camera-type eye development
positive regulation of DNA binding
positive regulation of transcription from RNA polymerase II promoter
spleen development
embryonic digestive tract morphogenesis
atrial cardiac muscle tissue morphogenesis
ventricular cardiac muscle cell development
somatotropin secreting cell differentiation
prolactin secreting cell differentiation
ventricular septum morphogenesis
left lung morphogenesis
pulmonary vein morphogenesis
superior vena cava morphogenesis
endodermal digestive tract morphogenesis
iris morphogenesis
cell proliferation involved in outflow tract morphogenesis
left/right axis specification
positive regulation of myoblast proliferation
negative regulation of transcription from RNA polymerase II promoter
brain development
heart development
skeletal muscle tissue development
anatomical structure morphogenesis
organ morphogenesis
pituitary gland development
neuron differentiation
lung development
regulation of cell proliferation
positive regulation of transcription, DNA-templated
cardiac muscle tissue development
cardiac muscle cell differentiation
digestive system development
multicellular organism development
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