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|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Rat, Mouse, Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified rat brain PKC.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||Assay Dependent|
|Western Blot (WB)||2-5 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Hint1 knockout results in a compromised activation of protein kinase C gamma in the brain.
13-3800 was used in western blot to investigate the role of in the function of brain protein kinase C gamma
|Zhang F,Fang Z,Wang JB||Brain research (1622:196)||2015|
Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis.
13-3800 was used in western blot to investigate the effect of CDR2 and CDR2L antibodies on Purkinje cell calcium homeostasis.
|Schubert M,Panja D,Haugen M,Bramham CR,Vedeler CA||Acta neuropathologica (128:835)||2014|
|Rat||1:400||Expression of spinal NMDA receptor and PKCgamma after chronic morphine is regulated by spinal glucocorticoid receptor.||Lim G,Wang S,Zeng Q,Sung B,Yang L,Mao J||The Journal of neuroscience : the official journal of the Society for Neuroscience (25:11145)||2005|
|Human||Not Cited||Protein kinase C betaII plays an essential role in dendritic cell differentiation and autoregulates its own expression.||Cejas PJ,Carlson LM,Zhang J,Padmanabhan S,Kolonias D,Lindner I,Haley S,Boise LH,Lee KP||The Journal of biological chemistry (280:28412)||2005|
|Rat||Not Cited||Distribution of gastrin-releasing peptide in the rat trigeminal and spinal somatosensory systems.||Takanami K,Sakamoto H,Matsuda KI,Satoh K,Tanida T,Yamada S,Inoue K,Oti T,Sakamoto T,Kawata M||The Journal of comparative neurology (522:1858)||2014|
Dynamic genotype-selective "phenotypic switching" of CGRP expression contributes to differential neuropathic pain phenotype.
13-3800 was used in immunohistochemistry - frozen section to test if calcitonin gene related peptide is the principal driver of tactile allodynia.
|Nitzan-Luques A,Minert A,Devor M,Tal M||Experimental neurology (250:194)||2013|
The majority of dorsal spinal cord gastrin releasing peptide is synthesized locally whereas neuromedin B is highly expressed in pain- and itch-sensing somatosensory neurons.
13-3800 was used in immunohistochemistry - frozen section to examine the expression of Grp and Nmb.
|Fleming MS,Ramos D,Han SB,Zhao J,Son YJ,Luo W||Molecular pain (8:null)||2012|
|Human||Not Cited||Amyloid plaques in cerebellar cortex and the integrity of Purkinje cell dendrites.||Li YT,Woodruff-Pak DS,Trojanowski JQ||Neurobiology of aging (15:1)||1994|
|Human||Not Cited||Human olfactory epithelium in normal aging, Alzheimer's disease, and other neurodegenerative disorders.||Trojanowski JQ,Newman PD,Hill WD,Lee VM||The Journal of comparative neurology (310:365)||1991|
DXS1179E; PKC-alpha; PKC-beta; PKC-gamma; PKCA; PKCB; PKCE; PKCG; PKCL; PRKACA; PRKC Pan; PRKCA; PRKCB1; PRKCD; PRKCE; PRKCG; PRKCH; PRKCI; PRKCL; PRKCQ; PRKCT; PRKCZ; protein kinase C gamma type; protein kinase C type I (gamma type); protein kinase C, gamma; SDK-1; Sphingosine-dependent protein kinase-1
PKC; PKC-gamma; PKCC; PKCG; PKCgamma; PKCI; Prkc; Prkcc; PRKCG; RATPKCI; SCA14