Invitrogen

PKC mu Recombinant Rabbit Monoclonal Antibody (ARC1919)

View all (33) PKC mu antibodies
Datasheet
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

MA5-38046

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC1919

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 200-300 of human PKC mu (Q15139)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2897964

Product Specific Information

Positive Samples: HeLa, HT-29, U-87MG, Mouse lung, Mouse testis, Mouse kidney, Rat lung, Rat testis, Rat kidney

Immunogen sequence: RRRRLSNVSL TGVSTIRTSS AELSTSAPDE PLLQKSPSES FIGREKRSNS QSYIGRPIHL DKILMSKVKV PHTFVIHSYT RPTVCQYCKK LLKGLFRQGL Q

Target Information

The PKC family of serine/threonine kinases, including PRKCN (PKD3), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. PKC mu activation is dependent on the phosphorylation of two activation loop sites, Ser744 and Ser748, via a PKC-dependent signaling pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZP586E0820; nPKC-D1; nPKC-D2; nPKC-mu; nPKC-nu; PKC mu; PKC nu; PKC u; PKC v; PKC-u; PKC-v; PKCmu; PKCu; PKCv; Protein kinase C mu type; Protein kinase C nu type; protein kinase C, mu; protein kinase C, nu; Protein kinase D; Protein kinase EPK2; Serine/threonine-protein kinase D1; Serine/threonine-protein kinase D2; Serine/threonine-protein kinase D3

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Gene Aliases: 4930557O20Rik; 5730497N19Rik; AI325941; EPK2; HSPC187; nPKC-D1; nPKC-D2; nPKC-mu; nPKC-NU; PKC-MU; PKC-NU; PKCM; Pkcnu; PKD; PKD1; PKD2; PKD3; PRKCM; PRKCN; PRKD1; PRKD2; PRKD3; RGD1308054

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UniProt ID: (Human) Q15139, (Human) Q9Y3X8, (Human) O94806, (Mouse) Q62101, (Rat) Q9WTQ1, (Rat) Q5XIS9, (Mouse) Q8BZ03, (Mouse) Q8K1Y2

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Entrez Gene ID: (Human) 5587, (Human) 25865, (Human) 23683, (Mouse) 18760, (Rat) 85421, (Rat) 292658, (Mouse) 101540, (Rat) 313834, (Mouse) 75292

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Function(s)
protein serine/threonine kinase activity protein kinase C activity protein binding ATP binding kinase activity identical protein binding metal ion binding protein kinase activity nucleotide binding transferase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
Process(es)
angiogenesis positive regulation of endothelial cell proliferation protein phosphorylation apoptotic process inflammatory response Golgi organization signal transduction integrin-mediated signaling pathway Ras protein signal transduction cell proliferation positive regulation of endothelial cell migration regulation of keratinocyte proliferation positive regulation of neuron projection development peptidyl-serine phosphorylation sphingolipid biosynthetic process regulation of protein stability positive regulation of CREB transcription factor activity positive regulation of peptidyl-serine phosphorylation cellular response to oxidative stress intracellular signal transduction cellular response to vascular endothelial growth factor stimulus positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of blood vessel endothelial cell migration innate immune response positive regulation of osteoblast differentiation positive regulation of angiogenesis negative regulation of endocytosis positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation vascular endothelial growth factor receptor signaling pathway Golgi vesicle transport positive regulation of NF-kappaB transcription factor activity regulation of release of sequestered calcium ion into cytosol negative regulation of cell death protein kinase D signaling positive regulation of histone deacetylase activity positive regulation of endothelial cell chemotaxis regulation of integrin-mediated signaling pathway adaptive immune response cell adhesion cell death positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of interleukin-2 production positive regulation of interleukin-8 production positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of cell adhesion T cell receptor signaling pathway positive regulation of T cell receptor signaling pathway positive regulation of sequence-specific DNA binding transcription factor activity endothelial tube morphogenesis positive regulation of ERK1 and ERK2 cascade mitophagy in response to mitochondrial depolarization positive regulation of intracellular signal transduction positive regulation of DNA biosynthetic process protein kinase C-activating G-protein coupled receptor signaling pathway immune system process nervous system development phosphorylation cell differentiation
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