Product References
Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis.
Pharmaceuticals (Basel, Switzerland)
Wubben TJ,Chaudhury S,Watch BT,Stuckey JA,Weh E,Fernando R,Goswami M,Pawar M,Rech JC,Besirli CG
Sat May 06 00:00:00 UTC 2023
Protein kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2.
Experimental cell research
Lai X,Liang Y,Jin J,Zhang H,Wu Z,Li G,Wang J,Zhang Z,Chen H,Zeng F,Deng F
Sun Jan 01 00:00:00 UTC 2023
Protein kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2.
Experimental cell research
Lai X,Liang Y,Jin J,Zhang H,Wu Z,Li G,Wang J,Zhang Z,Chen H,Zeng F,Deng F
Sun Jan 01 00:00:00 UTC 2023
Protein kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2.
Experimental cell research
Lai X,Liang Y,Jin J,Zhang H,Wu Z,Li G,Wang J,Zhang Z,Chen H,Zeng F,Deng F
Sun Jan 01 00:00:00 UTC 2023
Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS.
Acta pharmaceutica Sinica. B
Wu X,Liu L,Zheng Q,Ye H,Yang H,Hao H,Li P
Sun Jan 01 00:00:00 UTC 2023
Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS.
Acta pharmaceutica Sinica. B
Wu X,Liu L,Zheng Q,Ye H,Yang H,Hao H,Li P
Sun Jan 01 00:00:00 UTC 2023
Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS.
Acta pharmaceutica Sinica. B
Wu X,Liu L,Zheng Q,Ye H,Yang H,Hao H,Li P
Sun Jan 01 00:00:00 UTC 2023
Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS.
Acta pharmaceutica Sinica. B
Wu X,Liu L,Zheng Q,Ye H,Yang H,Hao H,Li P
Sun Jan 01 00:00:00 UTC 2023
Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS.
Acta pharmaceutica Sinica. B
Wu X,Liu L,Zheng Q,Ye H,Yang H,Hao H,Li P
Sun Jan 01 00:00:00 UTC 2023
Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS.
Acta pharmaceutica Sinica. B
Wu X,Liu L,Zheng Q,Ye H,Yang H,Hao H,Li P
Sun Jan 01 00:00:00 UTC 2023
Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS.
Acta pharmaceutica Sinica. B
Wu X,Liu L,Zheng Q,Ye H,Yang H,Hao H,Li P
Sun Jan 01 00:00:00 UTC 2023
Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS.
Acta pharmaceutica Sinica. B
Wu X,Liu L,Zheng Q,Ye H,Yang H,Hao H,Li P
Sun Jan 01 00:00:00 UTC 2023
Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS.
Acta pharmaceutica Sinica. B
Wu X,Liu L,Zheng Q,Ye H,Yang H,Hao H,Li P
Sun Jan 01 00:00:00 UTC 2023
Curcumin inhibits liquid-liquid phase separation of fused in sarcoma and attenuates the sequestration of pyruvate kinase to restore cellular metabolism.
Food & function
Shi WP,Lin WJ,Ge WY,Chen LL,Zhang TD,Guo WH,Liu JL,Yin DC
Mon May 22 00:00:00 UTC 2023
Exosomal lncRNA HOTAIR induces PDL1+ B cells to impede anti-tumor immunity in colorectal cancer.
Biochemical and biophysical research communications
Xie Z,Xia J,Jiao M,Zhao P,Wang Z,Lin S,Xing Y,Li Y,Lu Z,Zhong Z,Miao C,Zhou P,Qian J,Wang L,Zhang D,Gu J,Chu Y,Liu R
Sun Feb 12 00:00:00 UTC 2023
Exosomal lncRNA HOTAIR induces PDL1+ B cells to impede anti-tumor immunity in colorectal cancer.
Biochemical and biophysical research communications
Xie Z,Xia J,Jiao M,Zhao P,Wang Z,Lin S,Xing Y,Li Y,Lu Z,Zhong Z,Miao C,Zhou P,Qian J,Wang L,Zhang D,Gu J,Chu Y,Liu R
Sun Feb 12 00:00:00 UTC 2023
Development of a one-plasmid system to replace the endogenous protein with point mutation for post-translational modification studies.
Molecular biology reports
Ishrat I,Cheng A,Yu F,Guo J,Zhang P,Zhang K,Yang Z
Sat Jan 01 00:00:00 UTC 2022
Tetrahydroxy Stilbene Glucoside Alleviates Ischemic Stroke by Regulating Conformation-Dependent Intracellular Distribution of PKM2 for M2 Macrophage Polarization.
Journal of agricultural and food chemistry
Li M,Lu W,Meng Y,Zhang W,Wang F,Sun L,Xu Y
Wed Dec 14 00:00:00 UTC 2022
Salvianolic acid A regulates pyroptosis of endothelial cells via directly targeting PKM2 and ameliorates diabetic atherosclerosis.
Frontiers in pharmacology
Zhu J,Chen H,Le Y,Guo J,Liu Z,Dou X,Lu D
Sat Nov 26 00:00:00 UTC 2022
The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis.
Molecular cell
Zhu Y,Jin L,Shi R,Li J,Wang Y,Zhang L,Liang CZ,Narayana VK,De Souza DP,Thorne RF,Zhang LR,Zhang XD,Wu M
Thu Feb 03 00:00:00 UTC 2022
The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis.
Molecular cell
Zhu Y,Jin L,Shi R,Li J,Wang Y,Zhang L,Liang CZ,Narayana VK,De Souza DP,Thorne RF,Zhang LR,Zhang XD,Wu M
Thu Feb 03 00:00:00 UTC 2022
Pyruvate Kinase M2 Protects Heart from Pressure Overload-Induced Heart Failure by Phosphorylating RAC1.
Journal of the American Heart Association
Ni L,Lin B,Hu L,Zhang R,Fu F,Shen M,Yang J,Shi D
Tue Jun 07 00:00:00 UTC 2022
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Journal of immunology (Baltimore, Md. : 1950)
Fan TW,Daneshmandi S,Cassel TA,Uddin MB,Sledziona J,Thompson PT,Lin P,Higashi RM,Lane AN
Tue Nov 01 00:00:00 UTC 2022
Aurora A-mediated pyruvate kinase M2 phosphorylation promotes biosynthesis with glycolytic metabolites and tumor cell cycle progression.
The Journal of biological chemistry
Jiang Y,Wang T,Sheng D,Han C,Xu T,Zhang P,You W,Fan W,Zhang Z,Jin T,Duan X,Yuan X,Liu X,Zhang K,Ruan K,Shi J,Guo J,Cheng A,Yang Z
Tue Nov 01 00:00:00 UTC 2022
Aurora A-mediated pyruvate kinase M2 phosphorylation promotes biosynthesis with glycolytic metabolites and tumor cell cycle progression.
The Journal of biological chemistry
Jiang Y,Wang T,Sheng D,Han C,Xu T,Zhang P,You W,Fan W,Zhang Z,Jin T,Duan X,Yuan X,Liu X,Zhang K,Ruan K,Shi J,Guo J,Cheng A,Yang Z
Tue Nov 01 00:00:00 UTC 2022
Chemoproteomics reveals berberine directly binds to PKM2 to inhibit the progression of colorectal cancer.
iScience
Yan SH,Hu LM,Hao XH,Liu J,Tan XY,Geng ZR,Ma J,Wang ZL
Fri Aug 19 00:00:00 UTC 2022
Chemoproteomics reveals berberine directly binds to PKM2 to inhibit the progression of colorectal cancer.
iScience
Yan SH,Hu LM,Hao XH,Liu J,Tan XY,Geng ZR,Ma J,Wang ZL
Fri Aug 19 00:00:00 UTC 2022
Chemoproteomics reveals berberine directly binds to PKM2 to inhibit the progression of colorectal cancer.
iScience
Yan SH,Hu LM,Hao XH,Liu J,Tan XY,Geng ZR,Ma J,Wang ZL
Fri Aug 19 00:00:00 UTC 2022
Chemoproteomics reveals berberine directly binds to PKM2 to inhibit the progression of colorectal cancer.
iScience
Yan SH,Hu LM,Hao XH,Liu J,Tan XY,Geng ZR,Ma J,Wang ZL
Fri Aug 19 00:00:00 UTC 2022
Chemoproteomics reveals berberine directly binds to PKM2 to inhibit the progression of colorectal cancer.
iScience
Yan SH,Hu LM,Hao XH,Liu J,Tan XY,Geng ZR,Ma J,Wang ZL
Fri Aug 19 00:00:00 UTC 2022
Chemoproteomics reveals berberine directly binds to PKM2 to inhibit the progression of colorectal cancer.
iScience
Yan SH,Hu LM,Hao XH,Liu J,Tan XY,Geng ZR,Ma J,Wang ZL
Fri Aug 19 00:00:00 UTC 2022
Chemoproteomics reveals berberine directly binds to PKM2 to inhibit the progression of colorectal cancer.
iScience
Yan SH,Hu LM,Hao XH,Liu J,Tan XY,Geng ZR,Ma J,Wang ZL
Fri Aug 19 00:00:00 UTC 2022
Chemoproteomics reveals berberine directly binds to PKM2 to inhibit the progression of colorectal cancer.
iScience
Yan SH,Hu LM,Hao XH,Liu J,Tan XY,Geng ZR,Ma J,Wang ZL
Fri Aug 19 00:00:00 UTC 2022
The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells by encoding a novel protein NTRK2-243aa.
Cell death & disease
Zhao Y,Song J,Dong W,Liu X,Yang C,Wang D,Xue Y,Ruan X,Liu L,Wang P,Zhang M,Liu Y
Mon Sep 05 00:00:00 UTC 2022
Endoplasmic reticulum stress promotes sorafenib resistance via miR-188-5p/hnRNPA2B1-mediated upregulation of PKM2 in hepatocellular carcinoma.
Molecular therapy. Nucleic acids
Zhou B,Lu D,Wang A,Cui J,Zhang L,Li J,Fan L,Wei W,Liu J,Sun G
Fri Dec 03 00:00:00 UTC 2021
Endoplasmic reticulum stress promotes sorafenib resistance via miR-188-5p/hnRNPA2B1-mediated upregulation of PKM2 in hepatocellular carcinoma.
Molecular therapy. Nucleic acids
Zhou B,Lu D,Wang A,Cui J,Zhang L,Li J,Fan L,Wei W,Liu J,Sun G
Fri Dec 03 00:00:00 UTC 2021
Endoplasmic reticulum stress promotes sorafenib resistance via miR-188-5p/hnRNPA2B1-mediated upregulation of PKM2 in hepatocellular carcinoma.
Molecular therapy. Nucleic acids
Zhou B,Lu D,Wang A,Cui J,Zhang L,Li J,Fan L,Wei W,Liu J,Sun G
Fri Dec 03 00:00:00 UTC 2021
Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma.
Evidence-based complementary and alternative medicine : eCAM
Yang K,Wu K,Feng J,Yutian L,Zhu X,Xu D
Mon Apr 25 00:00:00 UTC 2022
Qian Yang Yu Yin Granule Improves Renal Injury of Hypertension by Regulating Metabolic Reprogramming Mediated by HIF-1α/PKM2 Positive Feedback Loop.
Frontiers in pharmacology
Qian L,Ren S,Xu Z,Zheng Y,Wu L,Yang Y,Wang Y,Li J,Yan S,Fang Z
Sat Jun 26 00:00:00 UTC 2021
Rab25 acts as an oncogene and participates in the regulation of aerobic glycolysis via PKM2 in gastric adenocarcinoma.
Translational cancer research
Zheng T,Huang L,Chen N,Xue H,Ni P,Huang G
Mon Feb 01 00:00:00 UTC 2021
Rab25 acts as an oncogene and participates in the regulation of aerobic glycolysis via PKM2 in gastric adenocarcinoma.
Translational cancer research
Zheng T,Huang L,Chen N,Xue H,Ni P,Huang G
Mon Feb 01 00:00:00 UTC 2021
Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
Life sciences
Yang W,Liu J,Hou L,Chen Q,Liu Y
Fri Jan 15 00:00:00 UTC 2021
Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
Life sciences
Yang W,Liu J,Hou L,Chen Q,Liu Y
Fri Jan 15 00:00:00 UTC 2021
Protocatechuic aldehyde protects cardiomycoytes against ischemic injury via regulation of nuclear pyruvate kinase M2.
Acta pharmaceutica Sinica. B
Wu X,Liu L,Zheng Q,Hao H,Ye H,Li P,Yang H
Mon Nov 01 00:00:00 UTC 2021
Protocatechuic aldehyde protects cardiomycoytes against ischemic injury via regulation of nuclear pyruvate kinase M2.
Acta pharmaceutica Sinica. B
Wu X,Liu L,Zheng Q,Hao H,Ye H,Li P,Yang H
Mon Nov 01 00:00:00 UTC 2021
Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia.
Molecular immunology
Li M,Lu H,Wang X,Duan C,Zhu X,Zhang Y,Ge X,Ji F,Wang X,Su J,Zhang D
Wed Dec 01 00:00:00 UTC 2021
Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia.
Molecular immunology
Li M,Lu H,Wang X,Duan C,Zhu X,Zhang Y,Ge X,Ji F,Wang X,Su J,Zhang D
Wed Dec 01 00:00:00 UTC 2021
Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia.
Molecular immunology
Li M,Lu H,Wang X,Duan C,Zhu X,Zhang Y,Ge X,Ji F,Wang X,Su J,Zhang D
Wed Dec 01 00:00:00 UTC 2021
Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia.
Molecular immunology
Li M,Lu H,Wang X,Duan C,Zhu X,Zhang Y,Ge X,Ji F,Wang X,Su J,Zhang D
Wed Dec 01 00:00:00 UTC 2021
Rapamycin facilitates differentiation of regulatory T cells via enhancement of oxidative phosphorylation.
Cellular immunology
Chen X,Li S,Long D,Shan J,Li Y
Thu Jul 01 00:00:00 UTC 2021
Dihydroartemisinin Inhibits the Proliferation of Leukemia Cells K562 by Suppressing PKM2 and GLUT1 Mediated Aerobic Glycolysis.
Drug design, development and therapy
Gao P,Shen S,Li X,Liu D,Meng Y,Liu Y,Zhu Y,Zhang J,Luo P,Gu L
Mon Mar 29 00:00:00 UTC 2021
Dihydroartemisinin Inhibits the Proliferation of Leukemia Cells K562 by Suppressing PKM2 and GLUT1 Mediated Aerobic Glycolysis.
Drug design, development and therapy
Gao P,Shen S,Li X,Liu D,Meng Y,Liu Y,Zhu Y,Zhang J,Luo P,Gu L
Mon Mar 29 00:00:00 UTC 2021
Dietary fish oil supplement induces age-specific contractile and proteomic responses in muscles of male rats.
Lipids in health and disease
Russ DW,Dimova K,Morris E,Pacheco M,Garvey SM,Scordilis SP
Thu Jul 09 00:00:00 UTC 2020
Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis.
Journal of experimental & clinical cancer research : CR
Feng J,Dai W,Mao Y,Wu L,Li J,Chen K,Yu Q,Kong R,Li S,Zhang J,Ji J,Wu J,Mo W,Xu X,Guo C
Thu Jan 30 00:00:00 UTC 2020
Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis.
Journal of experimental & clinical cancer research : CR
Feng J,Dai W,Mao Y,Wu L,Li J,Chen K,Yu Q,Kong R,Li S,Zhang J,Ji J,Wu J,Mo W,Xu X,Guo C
Thu Jan 30 00:00:00 UTC 2020
SQSTM1-dependent autophagic degradation of PKM2 inhibits the production of mature IL1B/IL-1β and contributes to LIPUS-mediated anti-inflammatory effect.
Autophagy
Zhang B,Chen H,Ouyang J,Xie Y,Chen L,Tan Q,Du X,Su N,Ni Z,Chen L
Wed Jul 01 00:00:00 UTC 2020
Danqi Pill Protects Against Heart Failure Post-Acute Myocardial Infarction via HIF-1α/PGC-1α Mediated Glucose Metabolism Pathway.
Frontiers in pharmacology
Zhang Q,Guo D,Wang Y,Wang X,Wang Q,Wu Y,Li C,Wang W,Wang Y
Thu Apr 14 00:00:00 UTC 2022
Supra-coronary aortic banding improves right ventricular function in experimental pulmonary arterial hypertension in rats by increasing systolic right coronary artery perfusion.
Acta physiologica (Oxford, England)
Tian L,Xiong PY,Alizadeh E,Lima PDA,Potus F,Mewburn J,Martin A,Chen KH,Archer SL
Sat Aug 01 00:00:00 UTC 2020
PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma.
Journal of experimental & clinical cancer research : CR
Feng J,Wu L,Ji J,Chen K,Yu Q,Zhang J,Chen J,Mao Y,Wang F,Dai W,Xu L,Wu J,Guo C
Fri May 17 00:00:00 UTC 2019
PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma.
Journal of experimental & clinical cancer research : CR
Feng J,Wu L,Ji J,Chen K,Yu Q,Zhang J,Chen J,Mao Y,Wang F,Dai W,Xu L,Wu J,Guo C
Fri May 17 00:00:00 UTC 2019
Regulation of the pyruvate metabolism node by monogene and polygene engineering of HEK-293 cells.
RSC advances
Xie L,Miao J,Li X,Yi X,Chu J
Thu Oct 31 00:00:00 UTC 2019
miR-122 inhibits cancer cell malignancy by targeting PKM2 in gallbladder carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Lu W,Zhang Y,Zhou L,Wang X,Mu J,Jiang L,Hu Y,Dong P,Liu Y
Fri Nov 06 00:00:00 UTC 2015
miR-122 inhibits cancer cell malignancy by targeting PKM2 in gallbladder carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Lu W,Zhang Y,Zhou L,Wang X,Mu J,Jiang L,Hu Y,Dong P,Liu Y
Fri Nov 06 00:00:00 UTC 2015
