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This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
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Protein Aliases: POU domain class 6 transcription factor 2; POU domain, class 6, transcription factor 2; Retina-derived POU domain factor 1; retina-derived POU-domain factor-1; RPF-1; Wilms tumor suppressor locus
Gene Aliases: POU6F2; RPF-1; RPF1; WT5; WTSL
UniProt ID: (Human) P78424
Entrez Gene ID: (Human) 11281
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