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FIGURE: 1 / 6
Positive Control: Rat brain tissue, SH-SY5Y, human liver carcinoma tissue, mouse brain tissue.
Subcellular Location: Cell junction, Cytoplasm, Cytoskeleton, Synapse, Synaptosome.
Neurabin I is a brain-specific protein which contains an F-actin binding domain, a PDZ domain, a transmembrane-protein-interacting-domain, and a coiled-coil region. As its structure suggests, neurabin I is a promiscuous protein binding to F-actin, protein phosphatase 1, TGN38, and p70 S6 kinase. Found exclusively in brain, this protein is highly concentrated in the synapse and has also been shown to be enriched in the lamellipodia of the growth cone during neuronal development. Neurabin I appears to be a bridging protein by targeting other proteins to the synapse or by linking membrane proteins to the actin cytoskeleton.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: actin-binding protein neurabin; neurabin 1; Neurabin I; Neurabin-1; Neurabin-I; neural tissue-specific F-actin binding protein; Neural tissue-specific F-actin-binding protein I; p180; PP1bp175; Protein phosphatase 1 regulatory subunit 9A; protein phosphatase 1, regulatory (inhibitor) subunit 9A; protein phosphatase 1, regulatory subunit 9A
Gene Aliases: 2810430P21Rik; 4930518N04Rik; 5330407E15; A230094E16Rik; BB181831; KIAA1222; mKIAA1222; Neb1; Neurabin-I; NRB; NRB1; NRBI; PPP1R9A
UniProt ID: (Human) Q9ULJ8, (Rat) O35867
Entrez Gene ID: (Human) 55607, (Mouse) 243725, (Rat) 84685
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